Sirolimus-tacrolimus combination immunosuppression.
نویسندگان
چکیده
A series of 32 recipients of liver, kidney, or pancreas transplants who were treated with sirolimus and low-dose tacrolimus experienced a low rate of rejection and excellent graft function without drug-related toxic effects.
منابع مشابه
Role of Immunosuppression Minimization Protocols in Renal Transplantation
The subject of transplant immunosuppression has generated significant interest in recent years. Excellent immunosuppression, advances in surgical technique, post-transplantation care, and infection control have resulted in excellent outcomes. There is widespread support for the notion that the fundamental objective in transplant immunology should be the achievement of specific graft toleran...
متن کاملinferior results with basic immunosuppression with sirolimus in kidney transplantation
Background: The introduction of sirolimus has provided the opportunity to develop an immunosuppressive regimen without the nephrotoxic calcineurin inhibitors. Methods: we conducted a first trial in 30 renal allograft recipients. Ten patients were followed prospectively and received sirolimus, to achieve a target blood level of 10 to 15 ng/ml, induction therapy with one dose of daclizumab, low-d...
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BACKGROUND The introduction of sirolimus has provided the opportunity to develop an immunosuppressive regimen without the nephrotoxic calcineurin inhibitors. METHODS We conducted a first trial in 30 renal allograft recipients. Ten patients were followed prospectively and received sirolimus, to achieve a target blood level of 10 to 15 ng/ml, induction therapy with one dose of daclizumab, low-d...
متن کاملDoes tacrolimus, in comparison with sirolimus, increase mycophenolic acid exposure in kidney transplant recipients?
Based on their study, “Increased mycophenolic acid exposure in stable kidney transplant recipients on tacrolimus as compared with , Braun et al. concluded that mycophenolic acid (MPA) exposure is greater in those on sirolimus: implication for pharmacokinetics ” tacrolimus treated patients than in those treated with sirolimus during maintenance immunosuppression after kidney transplant and sugge...
متن کاملOpen-Label, Randomized Study of Transition From Tacrolimus to Sirolimus Immunosuppression in Renal Allograft Recipients
UNLABELLED Calcineurin inhibitor-associated nephrotoxicity and other adverse events have prompted efforts to minimize/eliminate calcineurin inhibitor use in kidney transplant recipients. METHODS This open-label, randomized, multinational study evaluated the effect of planned transition from tacrolimus to sirolimus on kidney function in renal allograft recipients. Patients received tacrolimus-...
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ورودعنوان ژورنال:
- Lancet
دوره 355 9201 شماره
صفحات -
تاریخ انتشار 2000